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About Bipolar Disorder

How common is Bipolar Disorder?

Bipolar Disorder affects about 10 to 30 out of every 1000 people (or 1 to 3%) in the U.S.

Are patients with Bipolar Disorder always either manic or depressed?

No. Patients with Bipolar Disorder may recover from their depressed or manic episodes and have a normal mood state. However, they always run the risk of having futher episodes of depression or mania, especially if they are not on mood-regulating medication.

In addition, patients may be hypomanic. That is, they may have some symptoms of mania but not for long enough or severely enough to interfere with their functioning in a marked way. This can be difficult to distinguish from feeling "average" or "normal" in mood.

Finally, patients may have a mixed episode, during which they show symptoms of depression and mania concurrently or symptoms of one type or the other on different days within the same week.


What is the course of the illness?

While some people have only one episode of depression or mania without recurrence, the vast majority of patients (95%) have multiple episodes of depression and mania. At first, episodes may occur in response to stressful events, such as the break-up of a relationship, the death of a loved one, a move, or the loss of a job. Later on, episodes may come on "out of the blue," without connection to stressful events. There is evidence that the more episodes a person has, the more likely they are to have new episodes. In addition, the longer a person has the disorder, the shorter the time until the next episode. Therefore, as people have more episodes, they spend more and more time being ill.

The pattern of episodes can vary. Some people have single episodes of depression or mania with periods of normal mood in between. Others may have a manic episode immediately followed by a depressive episode, or a depressive episode immediately followed by a manic episode. Some people have both manic and depressed symptoms within a given episode.

Some people have what is know as rapid cycling, where they have many episodes within a short period of time. While the frequency of mood switches can vary greatly, a person is considered to have rapid cycling if he or she has four or more episodes per year. Thus, a frequency of episodes of every 3 months is sufficient to diagnose a rapid-cycling course.


What causes Bipolar Disorder?

Bipolar Disorder is thought to be caused by chemical imbalances in certain brain cells responsible for regulating emotions and behavior. These imbalances probably come about through an interaction of genetic factors and life experiences. It is not entirely genetic or entirely environmental; twin studies suggest it is approximately half-and-half. Examples of life experiences that can lead to bipolar disorder in people genetically predisposed to this illness include stressful life events, medical conditions (e.g., thyroid abnormalities), or use of medications like steroids. The disorder is clearly a medical illness, and differences in brain function can be identified in people who are depressed or manic compared with a person experiencing a normal mood state.


What are some complications of Bipolar Disorder? Going through depressed, manic, or mixed episodes can be very debilitating for the affected person and his or her family. The symptoms of the illness can interfere with a person's ability to take part in relationships and to function well at work. For instance, a person who is depressed may withdraw from friends and family or feel too irritable to be with him or her. He or she may be unable to concentrate on work or even to get out of bed to go to work. A person who is manic may have difficulty communicating with friends or family and may be irritable and potentially aggressive. He or she may be too disorganized and distracted to function at work.

Once the person recovers from the episode, he or she may face an abundance of debilitating consequences. People may find that their behavior has lost them their jobs, strained their relationships, and caused financial hardship or even homelessness. They may feel embarrassed by the way they behaved when depressed or manic. These hardships can lead to grief and demoralization. People often need help, such as psychotherapy and support groups to cope with these complications.

Suicide is another potential consequence resulting from Bipolar Disorder, particularly among patients who remain untreated. Approximately 25% of untreated patients with Bipolar Disorder commit suicide.


Can Bipolar Disorder be cured?

The disorder cannot be cured, but it can be treated or controlled. In this way it is similar to chronic medical conditions like diabetes or heart disease, and just like these conditions, better treatments are being developed.


How can you help someone with bipolar disorder who does not want treatment?

About 50% of patients with acute mania do not realize that they are experiencing manic symptoms. Family members may benefit from joining organizations like NAMI and MDDA to educate themselves and the individual who may have bipolar disorder. Talking to others with bipolar disorder who have experienced the same issues and benefitted from treatment can be quite helpful. Individuals should be encouraged to see a psychiatrist or other mental health professional to ask questions about mania and bipolar disorder and to respond to their doubts and concerns about being diagnosed with bipolar disorder.

The Massachusetts General Hospital
Bipolar Clinic and Research Program
50 Staniford Street, 5th Floor; Boston, MA 02114
P: (617) 726-5855 | F: (617) 726-6768

Treatment by clinic staff or MGH-affiliated clinics and studies can
NOT be arranged through this site or contact e-mail.


This web site, its contents, and contact information are designed for informational purposes only,
and must not be substituted for professional care.
Consult a physician or primary care doctor if you
believe that you are experiencing symptoms of any illness.
If you are experiencing an medical emergency, call 911 immediately.
© 2004 The MGH Bipolar Clinic and Research Program